Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) is an advanced fertility treatment that enhances traditional ICSI (Intracytoplasmic Sperm Injection) by selecting the healthiest sperm for fertilization. Using high-magnification microscopy, this method allows embryologists to examine sperm at a much higher resolution, identifying and selecting the best ones for injection into the egg.
What’s the Difference Between IMSI vs. ICSI?
While both IMSI and ICSI involve injecting a single sperm directly into an egg, the main difference is based on how the sperm is selected.
- ICSI: Uses standard magnification to choose a sperm based on general motility and shape and very general physical features of the sperm.
- IMSI: Uses a much higher magnification (up to 6000x) to detect even the smallest abnormalities in sperm structure leading to higher fertilization rates.
Ideal Candidates for This Procedure
IMSI is not necessary for every couple undergoing IVF, but it can be highly beneficial in specific cases:
- Men with high levels of sperm DNA fragmentation
- Couples who have experienced multiple failed IVF or ICSI cycles
- Cases of poor embryo development despite normal fertilization rates
- Severe male factor infertility, including abnormal sperm morphology or low sperm production.
The procedure
IMSI follows a structured process that ensures only the best sperm are selected for fertilization:
- A semen sample is collected and prepared for analysis.
- Sperm are examined under a high-resolution microscope to identify structural defects.
- The healthiest and most morphologically ideal sperm are chosen.
- Mature eggs are retrieved from the female partner and injected with the selected sperm.
- The fertilized eggs are monitored for proper growth before being transferred into the uterus.
Success Rates of This Procedure
IMSI has shown promising results in improving pregnancy outcomes for couples with male infertility. Studies indicate that IMSI can lead to:
- Higher fertilization rates compared to standard ICSI
- Improved embryo quality and reduced chances of genetic abnormalities
- Increased pregnancy and birth rates, especially in couples with recurrent IVF failures
* Success rates vary based on individual fertility factors
Potential Risks and Limitations
Though this is a highly effective technique, it does have limitations:
- The high-magnification sperm selection process takes longer than traditional ICSI.
- Due to the advanced equipment and expertise required, IMSI is more expensive than standard fertility treatments.
- Couples with good sperm quality may not see additional benefits from IMSI.
Financial Aspect
IMSI is a more expensive fertility treatment than standard ICSI due to the specialized technology and additional lab work involved. However, for couples with severe male infertility or repeated IVF failures, IMSI can improve outcomes, potentially reducing the number of cycles needed to achieve pregnancy.
While the upfront cost may be higher, the long-term benefits of increased success rates and healthier embryo development can make it a better long-term investment for those facing complex fertility challenges.
Mumbai has become a major city for advanced fertility treatments, offering some of the best reproductive clinics and highly experienced specialists. The city has fertility centres that are equipped with advanced technology, including high-magnification sperm selection techniques for IMSI. Couples seeking high success rates and medical expertise can find the best IMSI treatment in Mumbai, ensuring quality care and fertility solutions for their specific needs.
IMSI is a groundbreaking technique that offers hope to couples struggling with male infertility and repeated IVF failures. While it is not necessary for every fertility case, it provides significant advantages for those with poor sperm morphology and high DNA fragmentation.
Consulting a fertility expert can help determine if IMSI is the right choice based on the individual’s medical history and previous treatment outcomes.
References:
- https://pubmed.ncbi.nlm.nih.gov/32083321/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7033651/
- https://www.hfea.gov.uk/treatments/treatment-add-ons/intracytoplasmic-morphologic-sperm-injection-imsi/
- https://www.indoreinfertilityclinic.com/male-infertility-treatment/imsi-sperm-selection/
- https://www.shreeivfclinic.com/infertility/imsi/
Publisher